Inotek Pharmaceuticals Initiates Phase 2 Dose-ranging Trial of a Fixed-Dose Combination of Trabodenoson, a Novel Treatment for Glaucoma, and Latanoprost
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-Data Expected in 2017-
Trabodenoson, the Company’s lead clinical candidate, is a
first-in-class, highly selective adenosine A1 mimetic which
has been observed in Phase 2 clinical trials to reduce IOP. Latanoprost
is a prostaglandin analog and the most commonly used drug for lowering
IOP. Approximately 50% of glaucoma patients that receive a prostaglandin
require a second, adjunctive therapy to achieve sufficient IOP-lowering.
However, no combination product with a prostaglandin has been approved
“The Phase 2 trial of trabodenoson and latanoprost as
a fixed-dose combination in a single eye drop substantially broadens the
scope of Inotek’s trabodenoson development program,” said
About the Phase 2 Fixed-dose Combination Study of Trabodenoson and Latanoprost
The randomized, double-masked, Phase 2 dose-ranging trial will assess the overall benefit/risk profile of binocular topical application of different daily doses of trabodenoson (3.0% and 6.0%) when combined with latanoprost (0.005% or 0.0025%) for eight weeks in patients with ocular hypertension or primary open-angle glaucoma.
Three treatment combinations of trabodenoson and latanaprost will be investigated as well as two separate concentrations of latanoprost alone. The treatments are: trabodenoson 6%/latanoprost 0.005%, trabodenoson 3%/latanoprost 0.005%; trabodenoson 6%/latanoprost 0.0025%; latanoprost 0.005%; and latanoprost 0.0025%. Trabodenoson doses were selected to optimize intraocular pressure lowering, while maintaining the excellent tolerability and safety profile observed to date. Latanoprost doses were selected based on efficacy and safety profiles which vary based on dose.
The trial will enroll approximately 165 patients with an IOP greater than or equal to 25 mmHg and less than or equal to 34 mmHg; which represents the patients most likely to receive treatment for glaucoma or ocular hypertension. Following a placebo run-in period, treatment will be administered to both eyes for a total of eight weeks. Each subject will be assigned four weeks of morning and four weeks of evening dosing in a masked manner. Morning versus evening dosing is masked using placebo in addition to the active drug product.
For more information, please visit www.clinicaltrials.gov/ct2/show/NCT02829996.
Inotek Pharmaceuticals is a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of therapies for glaucoma and other eye diseases. The Company’s lead product candidate, trabodenoson, is a first-in-class, highly selective adenosine mimetic currently in Phase 3 development. Trabodenoson was developed in Inotek’s laboratories and is designed to restore the eye’s natural pressure control mechanism by targeting the adenosine A1 subreceptor. Additionally, the Company is evaluating the potential for selective adenosine mimetics to address optic neuropathies and other degenerative retinal diseases. For more information, please visit www.inotekpharma.com.
This press release contains forward-looking statements, which are subject to substantial risks, uncertainties and assumptions. These forward-looking statements often include words such as “believe,” “expect,” “anticipate,” “intend,” “plan,” “estimate,” “seek,” “will,” “may” or similar expressions. Accordingly, you should not place undue reliance on these forward-looking statements. All such statements speak only as of the date made, and the Company undertakes no obligation to update or revise publicly any forward-looking statements, whether as a result of new information, future events or otherwise.
Claudine Prowse, Ph.D., 781-552-4305
Vice President, Strategy and Investor Relations Officer